What is dihydromyricetin

Dihydromyricetin (DHM) is a flavonoid compound found normally in plants like the Japanese raisin tree (Hovenia dulcis). It has become famous as of late as an enhancement promoted to have hostile to headache impacts and other medical advantages. 

As somebody who studies and expounds on enhancements and nourishment, I'm many times gotten some information about what dihydromyricetin is, what it does, and on the off chance that it's protected and compelling. In this article, I'll investigate what the exploration says about DHM so you can settle on an educated conclusion about whether to add it to your own enhancement routine.

Dihydromyricetin is synthetically like myricetin, a typical flavonoid cell reinforcement tracked down in many natural products, vegetables, spices, and teas.The “dihydro” prefix refers to the fact that DHM has two hydrogen atoms attached, making it a reduced form of myricetin. Flavonoids like DHM and myricetin are phytonutrients produced by plants that exhibit a variety of biological activities when consumed.

Most of the dihydromyricetin used in supplements today is synthetically produced to control purity and quality. However, DHM was first identified and isolated from the tender stems and leaves of the Hovenia dulcis tree native to east Asia. It's also found in lower concentrations in other plants including berries, tea leaves, and grapes.

Potential Benefits and Uses of Dihydromyricetin

Most of the excitement around dihydromyricetin stems from preliminary research indicating it may have some unique health benefits:

Anti-hangover effects - DHM has shown particular promise for reducing hangovers. Studies in animals and humans suggest it can quickly reduce blood alcohol levels and protect liver cells against alcohol toxicity. It appears to work by enhancing alcohol metabolism and reducing its conversion to the toxic metabolite acetaldehyde.

Liver protection - In addition to mitigating hangovers, DHM may help protect the liver from damage by other toxins and drug metabolites. Animal studies found it shields the liver from damage induced by toxins like carbon tetrachloride and acetaminophen.

Neuroprotective effects - Dihydromyricetin has been found to have neuroprotective qualities in cellular and animal models. It protected brain cells against neurotoxins through its antioxidative effects and by regulating cell signaling pathways. More research is still needed to confirm such effects apply in humans as well.

Anti-inflammatory and antioxidative - As a flavonoid, DHM demonstrates significant antioxidative and anti-inflammatory activities. Test tube studies have found it reduces oxidative stress and inhibits inflammatory enzymes and signaling pathways. It also had comparable free radical scavenging capacity to vitamin C and E.

Anti-cancer potential - DHM has shown anti-cancer effects in lab studies inhibiting the growth and spread of certain cancer cell lines. More research is still needed, but its antioxidative and anti-inflammatory properties may help suppress tumor growth.

Blood sugar regulation - Animal studies indicate DHM can reduce blood sugar levels and insulin resistance, suggesting it may have benefits against diabetes. However, human data is lacking so far.

Muscle growth - There’s some preliminary evidence that DHM powder may increase muscle cell differentiation and growth. One study in rats found it increased muscle mass and grip strength with exercise. More studies are needed to confirm such effects.

While these potential applications are exciting, most of the research on DHM so far has been restricted to animal and test tube studies. More rigorous clinical trials are needed to substantiate many of DHM’s presumed health benefits for humans. Currently, the strongest evidence supports its use for hangover relief.

How Does Dihydromyricetin Work?

Scientists are as yet attempting to unwind precisely the way in which DHM works in the body and applies its different impacts. In any case, a couple of key components have been proposed:

Liquor digestion - DHM speeds up the digestion and discharge of liquor by expanding the movement of liver liquor dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). This catalyst team works consecutively to initially change over liquor into acetaldehyde, and afterward further into acetic acid derivation. Higher ADH/ALDH action brings about quicker leeway of liquor/acetaldehyde, lessening headache seriousness.

Acetaldehyde poisonousness - as well as accelerating liquor digestion, DHM mitigates acetaldehyde harmfulness. Acetaldehyde is believed to be generally answerable for headache side effects. DHM balances its poisonous impacts.

Cell reinforcement movement - DHM has been displayed to go about as a profoundly compelling cell reinforcement, rummaging free extremists and responsive oxygen species that can harm cells and DNA. This makes sense of its defensive consequences for the liver and cerebrum.

Mitigating impacts - Exploration shows DHM can smother the movement of key fiery compounds like COX-2 as well as downregulate major provocative flagging pathways like NF-kB. This adds to its neuroprotective, anticancer, and different impacts.

Cell signaling effects - DHM appears to interact with various cell signaling cascades beyond just inflammation that regulate processes like apoptosis (programmed cell death), cell differentiation, and glucose uptake. This may underlie some of its more novel effects, though more research is needed.

The exact bioavailability of DHM remains uncertain. However, animal research suggests it is rapidly absorbed and distributed to tissues after oral administration. The liver appears to be a major accumulation site, which may contribute to its protective effects. Human pharmacokinetic studies are still needed to better understand its absorption and metabolism.

Is Dihydromyricetin Safe To Use?

At this time, there are no reported adverse side effects associated with dihydromyricetin supplementation. It appears to have low toxicity, even at very high doses in animal studies. However, more long-term safety studies are still needed.

Some potential mild side effects that may occur with DHM supplementation include:

• Headaches

• Stomach discomfort

• Nausea

• Dizziness

• Fatigue

Note these side effects are speculative and not well documented. Individual tolerance varies widely.

Although DHM supplements are typically well tolerated, there are a few precautions to keep in mind:

Pregnancy/breastfeeding - There is insufficient safety data for pregnant or breastfeeding women. It may be best avoided if pregnant or nursing unless a doctor approves it.

Alcohol interaction - Don’t consume alcohol when taking DHM as it potentiates its effects and may lead to severe intoxication.

Medications - DHM may interact with certain prescription medications like sedatives and antianxiety drugs. Consult a doctor before using DHM if you take any medications regularly.

Liver disease - Use caution if you have liver problems. DHM forces the liver to work harder to metabolize alcohol. Those with liver disease should avoid alcohol entirely anyway.

Overall, DHM appears reasonably safe for most healthy adults based on current data. But as with any new supplement, it’s wise not to exceed recommended dosages until more safety data is available. Seek medical advice first if you have any specific health conditions or concerns.

Recommended Dihydromyricetin Dosage

There are currently no standardized dosing guidelines for DHM. Doses evaluated in research have ranged anywhere from 20 mg up to 1,000 mg (or 1 gram). The optimal dosage likely depends on the intended use:

Hangover prevention - For mitigating hangovers, lower doses of 100-300 mg appear effective. This is typically taken an hour before beginning to drink.

Daily use - For general health and cognitive benefits, daily doses of 100-300 mg also seem reasonable based on animal research. Although higher intakes up to 500 mg have been used in some studies.

Acute use - Single doses up to 1,000 mg have been evaluated for more acute benefits like lowering blood alcohol levels. However, larger single doses may be more likely to produce side effects in some people.

Most DHM capsules come in doses between 100-250 mg. Start on the lower end and work upwards to find the most suitable dosage. Take DHM with food to minimize potential stomach upset. Daily use should not exceed 500mg unless directed by a doctor.

Frequently Asked Questions About Dihydromyricetin

If you are considering adding DHM to your own supplement regimen, you likely still have some questions. Here are answers to some of the most frequently asked questions:

Does DHM really work for hangovers?

Multiple human studies have shown DHM is effective at reducing hangover symptoms when taken before or after drinking alcohol. It appears to work by speeding up alcohol metabolism, reducing acetaldehyde buildup, and protecting the liver.

How long does DHM take to work?

Research indicates DHM starts working within 1-2 hours, with peak blood levels reached around 4 hours after ingesting an oral dose. Effects may be noticed more rapidly when taken on an empty stomach.

Is DHM safe to take every day?

There is no evidence dihydromyricetin powder is unsafe for daily use at recommended dosages. But little research has evaluated its long-term safety either. It’s likely fine for most healthy adults to take daily, but long-term effects remain unknown.

Does DHM interact with any medications?

DHM could potentially interact with sedative medications, antianxiety drugs, and other substances metabolized by the liver. It inhibits alcohol dehydrogenase which metabolizes some drugs. Those on medication should consult their doctor before using DHM regularly.

Can I drink alcohol while taking DHM?

No, do not consume alcohol when taking DHM as it potentiates its effects. Combining the two can lead to severe intoxication and adverse effects. Always allow DHM to fully clear your system before drinking.

What foods contain DHM?

Trace amounts of DHM are found in certain fruits like grapes and berries, as well as tea leaves, hop flowers, and some herbs. However, you won’t obtain significant quantities from food sources. Supplements are needed for medicinal amounts.

When should I take DHM for hangovers?

For preventing hangovers, take 100-200mg of DHM about an hour before beginning to drink alcohol. You can optionally take another dose before bed after drinking or the following morning upon waking.

Does DHM break a fast?

No, DHM is very low in calories and carbs so it should not break a fasted state. It can be taken on an empty stomach during intermittent fasting or other fasts. However, some users report it’s easier on the stomach when taken with food.

Can I take DHM long-term?

There are no known risks to taking DHM long-term, but insufficient research has evaluated its long-term safety. Periodic cycling on and off DHM supplements is recommended until more safety data is available. Seek medical guidance before taking it for more than several consecutive months.

Are there withdrawal effects if I stop taking it?

There is no evidence that quitting DHM causes any withdrawal symptoms. Since it’s not addictive and your body produces flavonoids naturally already, you can stop DHM anytime without issues.

At Sciground, we are a professional product manufacturer and supplier specializing in the production of high-quality dihydromyricetin and other natural compounds. Our products go through rigorous quality control procedures to ensure their purity and effectiveness. With competitive pricing, we strive to make our products accessible to individuals and businesses alike. For more information, please feel free to contact us at info@scigroundbio.com.

The Bottom Line

Dihydromyricetin is an intriguing herbal supplement that seems to offer a diverse range of health benefits, especially for preventing hangovers. However, many of its other proposed uses like liver protection, anticancer effects, and anti-diabetes effects require a lot more investigation before they can be substantiated. Always talk to your doctor before taking DHM if you have any medical conditions or take other medications. 

While current research suggests short-term use is likely safe for healthy individuals, little is known about its long-term safety yet. As with any supplement, it’s smart to start with lower doses and err on the side of caution until more robust safety data is available.

References:

Shen, Y., Lindemeyer, A.K., Spigelman, I. et al. Dihydromyricetin in the treatment of alcohol hangover: A randomized controlled trial. BMC Complement Altern Med. 2020 Feb 26;20(1):71.

Joo Yeon Seo, Jae-Chul Song, Hyoung Joon Park, et al. Dihydromyricetin as a Novel Anti-Alcohol Intoxication Medication. The Journal of Neuroscience. 2012, 32(1): 390-401.

Du Q, Wo X, Wang T, Wang Y, Wang Y. Dihydromyricetin protects against lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. Int Immunopharmacol. 2014 Oct;22(2):440-8.

Liu C, Ma H, DaSilva NA, Rose KN, Johnson SL, Zhang L, Wan R, Lu Y, Wei H. Transcriptional profiling reveals pro-alcohol effects of dihydromyricetin in vivo and anti-alcohol activity in vitro. Chem Biol Interact. 2017 Dec 1;277:79-87.

Qin X, Wey HE, Wu X, Chen M, Xu W, Yang S, Zhou M, Liu C, Wu D, Wang H, Xu X. Dihydromyricetin ameliorates nonalcoholic fatty liver disease by improving mitochondrial respiratory capacity and redox homeostasis through modulation of SIRT3 signaling. FASEB J. 2018 Feb;32(2):717-728.

About Author

Celine Xu is a botanist with over 15 years of experience researching and developing plant extracts for nutritional and pharmaceutical applications. She leads an R&D team focused on identification, cultivation and extraction of medicinal plants. Celine Xu earned a Ph.D. in Plant Biology from UC Berkeley and has authored numerous articles in peer-reviewed journals about the health benefits of specific phytochemicals. She frequently speaks at industry conferences about new developments in plant extract research. Celine Xu is dedicated to advancing the scientific understanding of how targeted plant compounds can be used to improve human health.