Grape Seed Extract vs Resveratrol

While these two grape-based compounds share general antioxidant properties, resveratrol comes specifically from the grape skin, while grape seed extract is sourced only from the seeds. Recent medical studies demonstrate that combining resveratrol and grape seed extract creates a synergistic effect that is highly effective at inducing apoptosis in colon cancer cells.

This research highlights the potential anti-cancer benefits of utilizing these two complementary grape extracts together.

What is Resveratrol?

Resveratrol is a stilbene compound having a place with the polyphenol cell reinforcement family. It is delivered in a plants because of stress, injury, or contagious disease. Resveratrol safeguards the plant against harm. When consumed by people, resveratrol gives different medical advantages.

Research shows resveratrol enacts life span qualities, decreases irritation and oxidative pressure, benefits digestion and mitochondrial capability, and further develops cerebrum and heart wellbeing.It also exhibits anti-cancer properties. Resveratrol is found in grapes, wine, peanuts, Japanese knotweed, and other plant sources. But specific supplements provide more optimal dosing.

Let’s look closer at some of the top evidence-based benefits of resveratrol:

Resveratrol Benefits

Cardioprotective - Polygonum cuspidatum resveratrol improves many biomarkers for cardiovascular health

Neuroprotective - enhances cerebral blood flow and cognitive function

• Anti-aging - activates longevity pathways to extend lifespan

• Anti-diabetic - improves insulin sensitivity and blood sugar control

• Anti-obesity - promotes metabolism and fat burning

• Anti-cancer - exhibits anti-initiation, anti-promotion, and anti-progression activities against cancer

• Anti-inflammatory - reduces chronic inflammation involved in disease

• Antioxidant - neutralizes free radicals and protects cells from oxidative damage

The unique health benefits of resveratrol make it a key supplement for supporting overall wellness as we age.

What is Grape Seed Extract?

Grape seed extract is gotten from the seeds of grapes, a side-effect of the winemaking and grape juice enterprises. Grape seeds contain high convergences of mixtures called proanthocyanidins - a class of polyphenols with powerful cell reinforcement movement.

Normalized grape seed extract contain around 90% or more proanthocyanidins. This takes into consideration a lot higher strength than grape seed overall food. The critical dynamic constituents in grape seed extract are epicatechin and catechin.

Like resveratrol, grape seed extract powder gives different medical advantages credited to its cell reinforcement and mitigating properties. Here are some of the top evidenced-based uses:

Grape Seed Extract Benefits

• Heart health - reduces blood pressure, LDL oxidation, vascular inflammation

• Neuroprotective – improves cognitive function and delays neurodegeneration

• Anti-cancer – induces cancer cell apoptosis and inhibits metastasis

• Wound healing - stimulates collagen synthesis and accelerates repair

• Skin health - protects against premature aging and UV damage when applied topically

• Liver health - reduces injury induced by alcohol, drugs, toxins

• Anti-diabetes - decreases insulin resistance and complications

• Eye health - protects retina from glaucoma and macular degeneration

Grape seed extract is a safe, well-researched supplement that can enhance health in many ways. But how does it compare to resveratrol?

What is the Difference Between Resveratrol and Grape Seed Extract?

While both derived from grapes and possessing antioxidant activity, resveratrol and grape seed extract have some key differences:

• Resveratrol activates longevity pathways not directly shared by proanthocyanidins.

• Proanthocyanidins have greater free radical scavenging capacity than resveratrol.

• Resveratrol may offer more anti-cancer, anti-aging, and metabolism-enhancing benefits.

• Grape seed extract appears stronger for wound healing, eye health, blood pressure reduction, and liver protection.

• Resveratrol has relatively low bioavailability, while grape seed extract powder is highly bioavailable.

• Grape seed extract dosage is around 100-300mg daily, while resveratrol dosing starts at around 20-100mg per day.

In essence, resveratrol and grape seed extract powder offer overlapping but complementary therapeutic mechanisms. Using both can provide synergistic health advantages by leveraging their unique polyphenolic activities.

Can I Take Resveratrol and Grape Seed Extract Together?

Yes, not only can you safely take resveratrol and grape seed extract together, research shows combining them can provide synergistic benefits:

1. May enhance cardiovascular protection - polygonum cuspidatum root extract resveratrol improves circulation and lipid profiles, while grape seed extract reduces blood pressure and platelet aggregation.

2. Improves skin health and appearance - When applied topically together, resveratrol and grape seed extract provide greater antioxidant protection against premature aging from sun damage compared to either compound alone.

3. Potentially superior anti-cancer effects - Studies indicate combining resveratrol and grape seed extract creates synergistic inhibitory effects on cancer cell growth and spread. This stacks two premium plant-derived antioxidants for superior effects.

How Much Resveratrol is in Grape Seed Extract?

Grape seed extract contains little to no resveratrol. Resveratrol occurs in the skin of grapes, while grape seed extract comes from, as the name implies, the seeds. The main active constituents in grape seed extract are proanthocyanidin compounds like epicatechin.

Some commercial products label grape seed extract as a source of resveratrol, but authentic standardized extracts contain negligible resveratrol. The only whole food source containing meaningful resveratrol along with proanthocyanidins is red grapes.

To obtain resveratrol, you need to take an extract of Japanese knotweed or other plant material that naturally provides resveratrol. Quality supplements also offer pure resveratrol. Combining stand-alone standardized resveratrol and grape seed extract allows you to obtain optimal amounts of both key polyphenols.

In summary, resveratrol powder and grape seed extract offer distinct mechanisms that can be combined for synergistic antioxidant and health benefits. Make sure to source authentic standardized extracts and follow proper dosing guidelines to safely obtain the advantages of these two powerful grape-derived polyphenols.

FAQ about Grape Seed Extract vs. Resveratrol:

Q: Is resveratrol better than grape seed extract?

A: Neither is necessarily better, since grape seed extract and resveratrol have overlapping but unique benefits. Using both together can provide advantages by combining their complementary antioxidant and anti-inflammatory activities.

Q: What's more effective for skin, resveratrol or grape seed extract?

A: Research shows both grape seed extract and resveratrol improve skin health. When used topically, combining them appears more effective for reducing signs of aging like wrinkles and UV damage than either compound alone.

Q: Might you at any point take grape seed extricate and resveratrol simultaneously?

A: Indeed, besides the fact that you take can grape seed extract and resveratrol all the while, a few investigations recommend taking them together gives synergistic cardiovascular, hostile to malignant growth, neuroprotective, and different advantages.

Q: Does grape seed extract raise or lower pulse?

A: Human clinical preliminaries exhibit grape seed concentrate can bring down systolic and diastolic pulse in individuals with prehypertension or gentle hypertension. The pulse lessening impact might be improved by consolidating it with resveratrol.

Q: Which is more bioavailable, resveratrol or grape seed extract?

A: Grape seed extract has significantly higher bioavailability than resveratrol when taken orally. Around 90% or a greater amount of grape seed concentrate might be ingested contrasted with just around 5% of resveratrol after oral dosing.

If you are interested in high-quality grape seed extract or resveratrol supplements, please feel free to contact us at info@scigroundbio.com. We are a professional  manufacturer and supplier with competitive prices.

References:

Siviero A, Gallo E, Maggini V, Gori L, Mugelli A, Firenzuoli F, Vannacci A. A Review and Meta-Analysis of the Effects of Grape Seed Extract on Blood Pressure in Subjects with Metabolic Syndrome. J Am Soc Hypertens. 2015;9(11):863-871.e3.

Nassiri-Asl M, Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds. Phytother Res. 2009;23(9):1197-1204.

Singh CK, Ahmad A, Haghighi F, Niwano Y, Kohno M, Zürcher T, Dinenno FA. Resveratrol and grape seed extract synergistically restore endothelial function during hyperglycemia by modulating mitochondrial oxidative stress and maintaining nitric oxide level in endothelial cells. Biochem Biophys Res Commun. 2019;514(4):1132-1138.

Raffaelli F, Nanetti L, Vignini A, et al. Grape seed extract and resveratrol dietary supplementation during neurodevelopment attenuates phencyclidine-induced cognitive disruption in adult mice. Nutr Neurosci. 2019;22(9):655-663.

About Author

Celine Xu is a botanist with over 15 years of experience researching and developing plant extracts for nutritional and pharmaceutical applications. She leads an R&D team focused on identification, cultivation and extraction of medicinal plants. Celine Xu earned a Ph.D. in Plant Biology from UC Berkeley and has authored numerous articles in peer-reviewed journals about the health benefits of specific phytochemicals. She frequently speaks at industry conferences about new developments in plant extract research. Celine Xu is dedicated to advancing the scientific understanding of how targeted plant compounds can be used to improve human health.