Fisetin vs Quercetin

Quercetin is a senolytic with less potency than fisetin. What's more, it chips away at its own, without the expected results of malignant growth drugs. According to a cell study that was published in the journal Aging, it killed off about 70% of senescent cells without harming healthy human cells.

What is Fisetin?

Fisetin is a flavonoid compound found naturally in many fruits and vegetables. Chemically, it is known as 3,3’,4’,7-tetrahydroxyflavone. Fisetin gives color to plants and also protects them from stress. It can be found in:

• Strawberries

• Apples

• Persimmons

• Grapes

• Onions

• Cucumbers

Fisetin has been studied for its role as an antioxidant that reduces oxidative stress in cells. It also exhibits anti-inflammatory, anticancer, anti-aging and neuroprotective properties in studies. Some of the potential benefits of fisetin include:

• Protects brain function and improves memory

• Reduces markers of aging like senescence

• Protects nerve cells and promotes nerve growth

• Prevents DNA damage and has anticancer effects

• Reduces inflammation and allergies

• Helps maintain bone density

• May protect against heart disease

• Improves immune function

• Has antidiabetic effects

Overall, fisetin is gaining interest for its ability to protect cells against damage, lower inflammation, slow aging, and maintain healthy body function.

What is Quercetin?

Quercetin is also a naturally occurring flavonoid found in many fruits, vegetables, teas, herbs and grains. Its chemical structure is 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one. Good food sources of quercetin include:

• Capsers

• Red onions

• Kale

• Broccoli

• Berries

• Apples

• Tea

• Red wine

Like fisetin, quercetin powder is a powerful antioxidant that helps combat free radicals and oxidative damage. It also exhibits strong anti-inflammatory properties. Some of quercetin’s possible benefits are:

• Reduces inflammation

• Fights allergies and histamine release

• May lower blood pressure

• Helps control blood sugar

• Exhibits anticancer properties

• Protects cardiovascular health

• Improves endurance and exercise capacity

• Lessens hazard of neurodegenerative sickness

By and large, quercetin is valuable in diminishing oxidative pressure, irritation, and hazard of ongoing illnesses like diabetes, malignant growth and coronary illness.

Contrast Among Fisetin and Quercetin

However fisetin and quercetin have comparable capabilities as cancer prevention agent and mitigating flavonoids, there are a few vital contrasts between them:

• Structure: Fisetin has more hydroxyl groups than bulk quercetin in its molecular structure. This gives fisetin higher antioxidant capacity.

• Bioavailability: Fisetin appears to have better bioavailability than quercetin when ingested. It achieves higher plasma concentrations and stays in the blood longer.

• Mechanisms: Fisetin displays specific benefits like anti-aging because it can activate particular pathways like the NRF2 pathway. Quercetin has broader effects.

• Cancer activity: Fisetin has been found to have stronger inhibitory activity against cancer cells compared to quercetin in some studies.

• Neuroprotection: Fisetin’s neuroprotective abilities in promoting nerve growth may be superior to those of bulk quercetin powder.

• Clinical research: Quercetin has been more extensively researched in human clinical trials whereas fisetin studies are mostly limited to in vitro and animal models.

• Overall, both fisetin and quercetin have overlapping benefits but fisetin appears to have higher antioxidant power, better bioavailability, and unique senolytic (anti-aging) properties compared to quercetin.

Choosing the Right Flavonoid For You

When choosing between taking fisetin or quercetin supplements, here are some factors to consider:

• Your health goal - If you want to target brain health, nerve growth and anti-aging; fisetin may be more suitable. For allergies, blood pressure, endurance or cardiovascular health; quercetin may be more ideal.

• Bioavailability preferred - If you want the flavonoid with better absorption to maximize benefits, fisetin would be the better choice.

• Cancer prevention - Early research shows fisetin may inhibit cancer cell growth more than quercetin.

• Budget - Quercetin is more affordable than fisetin in supplement form. So if the cost is a limiting factor, quercetin presents better value.

• Research backing - Quercetin has been studied longer in human trials. So for some, quercetin may provide more trustworthy evidence.

• Synergistic stacking - You can take both fisetin and quercetin together for a synergistic effect since they provide complementary benefits.

As with any new supplement, start at a low dosage and monitor effects. Consult a healthcare provider before adding flavonoid supplements, especially if you take any medications or have underlying health conditions. While both fisetin and quercetin are considered safe, side effects can still occur on high dosages like digestive upset. Overall, flavonoids like fisetin and quercetin are emerging as beneficial plant compounds that can help protect health and combat disease.

Where to buy Quercetin and Fisetin?

If you need to buy bulk Quercetin and Fisetin, please contact us at email:info@scigroundbio.com.

Questions and Answers About Quercetin and Fisetin 

Are Quercetin and Fisetin Antioxidants?

Yes, the powerful antioxidants quercetin and fisetin aid in the body's removal of harmful free radicals. Many of their health benefits are thought to be due to their antioxidant properties.

Where are fisetin and quercetin found?

Fisetin and quercetin are normally tracked down in many organic products, vegetables, nuts, teas, spices and grains. Some normal food sources are strawberries, apples, onions, escapades, kale, tea and red wine.

How are fisetin and quercetin unique?

In comparison to quercetin, fisetin has unique anti-aging properties, a higher bioavailability, and a more potent antioxidant effect. In any case, quercetin has been to a greater extent concentrated on in human preliminaries.

What are the symptoms of fisetin and quercetin?

Both flavonoids cause few side effects when taken in moderation. High supplemental doses may potentially cause headaches, digestive issues or dizziness.

Can I take fisetin and quercetin together?

Yes, stacking fisetin and quercetin together is safe for most people and provides a synergistic effect since their mechanisms are complementary. Start with low dosages of each.

Do fisetin and quercetin affect estrogen levels?

In animal studies, very high doses of fisetin and quercetin may impact estrogen receptors. But normal supplemental dosages are unlikely to significantly affect estrogen or hormones.

Are fisetin and quercetin absorbed well?

Fisetin appears to have significantly better absorption and higher bioavailability compared to quercetin when ingested orally based on rat studies.

How long do the effects of fisetin and quercetin last?

Pharmacokinetic studies show fisetin remains in the blood plasma for a longer duration (up to 12 hours) compared to quercetin. This extends fisetin’s window of activity.

Do fisetin and quercetin really work?

While human data is still limited, the promising results seen in preliminary cell and animal studies suggest that fisetin and quercetin likely exert significant health and anti-aging benefits in humans as well. Ongoing research should shed more light.

References:

Touil, Yasmine S., et al. "Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite." Biochemical pharmacology 124 (2016): 42-53.

Yashin, A., Yashin, Y., Xia, X., & Nemzer, B. (2017). Antioxidant activity of spices and their impact on human health: A review. Antioxidants, 6(3), 70.

Maher, Pamela, et al. "Fisetin acts on multiple pathways to reduce the impact of age and disease on CNS function." Ageing research reviews 23 (2015): 139-158.

Boncler, Magdalena, Magdalena Golanski, and Cezary Watala. "Quercetin and its derivatives: chemical structure and bioactivity - a review." Polish Journal of Food and Nutrition Sciences 69 (2019).

D’Andrea, Giuseppe. "Quercetin: A flavonol with multifaceted therapeutic applications?." Fitoterapia 106 (2015): 256-271.

Lines, Tiffany C., and Paula R. Stevenson. "Fisetin." Nutrients 13.6 (2021): 1944.

Pietta, Piergiorgio G. "Flavonoids as antioxidants." Journal of natural products 63.7 (2000): 1035-1042.

About Author

Celine Xu is a botanist with over 15 years of experience researching and developing plant extracts for nutritional and pharmaceutical applications. She leads an R&D team focused on identification, cultivation and extraction of medicinal plants. Celine Xu earned a Ph.D. in Plant Biology has authored numerous articles in peer-reviewed journals about the health benefits of specific phytochemicals. She frequently speaks at industry conferences about new developments in plant extract research. Celine Xu is dedicated to advancing the scientific understanding of how targeted plant compounds can be used to improve human health.