Dihydromyricetin vs Myricetin

Myricetin has a more grounded liking to ox-like lactoferrin than dihydromyricetin. Myricetin prompted more conformity changes in BLF than dihydromyricetin. Cancer prevention agent action of flavonoids and their edifices with cow-like lactoferrin were evaluated.

What is Dihydromyricetin?

Dihydromyricetin, also known as ampelopsin, is a natural flavonoid compound found in various plants. It is structurally classified as a pyranoflavonoid and derived from the flavonol myricetin. Dihydromyricetin can be found in:

• Hovenia dulcis (Japanese raisin tree)

• Ampelopsis grossedentata (wild grape vine)

• Myrica rubra (Chinese bayberry)

• Myrica nagi (Japanese bayberry)

Dihydromyricetin exhibits potent antioxidant, anti-inflammatory, anticancer, hepatoprotective, neuroprotective, and other effects that support health. It shows particular promise for liver protection, hangover relief, blood sugar control, and brain health. Let’s look closer at some of the top science-backed benefits of this flavonoid.

Dihydromyricetin Benefits

Extensive research demonstrates dihydromyricetin provides the following key wellness benefits:

Liver Protection

Protects liver cells from toxins and prevents liver damage through antioxidant, anti-inflammatory, and antifibrotic effects. Also reduces elevated liver enzymes.

Hangover Relief

Quickly breaks down alcohol metabolites and minimizes hangover symptoms. Also prevents alcohol withdrawal.

Memory Enhancement

Enhances cognitive function, memory, and neuroplasticity. Protects brain cells against neurotoxins and neurodegeneration.

Blood Sugar Control

Improves insulin sensitivity and glucose metabolism. Helps regulate blood sugar levels in diabetes.

Anti-Cancer Effects

Selectively targets and induces apoptosis in cancer cells while sparing normal cells. Inhibits proliferation, metastasis, and drug resistance.

The unique health benefits of dihydromyricetin bulk make it a promising therapeutic and preventive agent. However, more clinical studies in humans are still needed to further evaluate efficacy and optimal dosing.

What is Myricetin?

Myricetin is a naturally occurring flavonoid found in many fruits, vegetables, teas, herbs, and medicinal plants. Food sources rich in myricetin include:

• Onions

• Blueberries

• Garlic

• Bok choy

• Broccoli

• Green tea

• Red wine

Myricetin belongs to the flavonols subclass of flavonoids and consists of a fifteen carbon skeleton structure. It provides antioxidant, anti-inflammatory, anticancer, antidiabetic, neuroprotective, cardioprotective, and other beneficial effects. Here are some of the top science-backed uses of myricetin:

Myricetin Benefits

Extensive research shows myricetin may provide the following health benefits:

Powerful Antioxidant

Strongly scavenges numerous reactive oxygen species and boosts endogenous antioxidants like glutathione. Protects cells against oxidative damage.

Anti-Cancer Activity

Selectively toxic to cancer cells by inhibiting proliferation, metastasis, and angiogenesis. Non-toxic to normal cells at similar doses.

Improves Heart Health

Lowers LDL cholesterol, reduces platelet aggregation, enhances vasodilation, and provides other cardioprotective effects.

Anti-Diabetic Effects

Lowers elevated blood sugar, improves insulin sensitivity, protects pancreatic beta cells, and reduces diabetes complications.

Neuroprotective Effects

Crosses the blood-brain barrier to exert antioxidant, anti-inflammatory and pro-neuronal effects. May benefit cognitive and mental disorders.

While myricetin research remains preliminary, its multifaceted therapeutic actions make it a promising preventive and intervention agent for chronic diseases. Further clinical studies to confirm efficacy in humans remains an important next step.

What is the Difference Between Dihydromyricetin and Myricetin?

Although closely related, there are some key differences between dihydromyricetin and myricetin:

Source

Dihydromyricetin is primarily derived from Hovenia dulcis, while myricetin is more widespread and abundant in common fruits and vegetables.

Structure

Dihydromyricetin is the dihydro derivative of myricetin, meaning it contains two hydrogen atoms attached to the 4’ and 5’ positions of the B ring. This alters its chemical properties.

Absorption

Dihydromyricetin exhibits substantially greater bioavailability than myricetin when administered orally, which may enhance its effects.

Effects

While both are antioxidants, dihydromyricetin bulk powder appears stronger for liver protection, hangover relief, and memory enhancement, while myricetin shows greater promise for heart health and diabetes support.

Toxicity

Wholesale dihydromyricetin powder demonstrates very low toxicity, while high doses of myricetin may be harmful. However, moderate intake of both flavonoids appears quite safe.

In summary, dihydromyricetin and myricetin are structurally similar flavonoids with overlapping benefits, but some distinct differences in their absorption, bioactivity, and therapeutic applications. Using both synergistically may provide advantages by leveraging their complementary mechanisms of action.

As research continues, I expect these fascinating flavonoids will find increasing therapeutic and preventive roles leveraging their potent antioxidant, anti-inflammatory, and anticancer properties. Make sure to consume food sources rich in myricetin, while using quality dihydromyricetin supplements to obtain optimal intakes of these health-promoting compounds.

FAQ about Dihydromyricetin and Myricetin:

Q: Which is better for the liver, dihydromyricetin or myricetin?

A: Research indicates dihydromyricetin is more potent for protecting the liver by reducing injury from toxins and improving liver function markers.

Q: Is dihydromyricetin safe to take daily?

A: Available data suggests dihydromyricetin is safe for long-term daily use at moderate supplemental doses. It has very low toxicity and few side effects.

Q: Does myricetin lower blood pressure?

A: Yes, human and animal studies show myricetin enhances vasodilation and reduces hypertension through antioxidant effects that improve endothelial function.

Q: Are dihydromyricetin and myricetin antioxidants?

A: Yes, both compounds are very powerful antioxidants that can scavenge numerous free radicals and enhance the body's endogenous antioxidant systems.

Q: What foods are high in myricetin?

A: Good dietary sources of myricetin include onions, blueberries, chia seeds, kale, broccoli, cabbage, green tea, and red wine. DHM supplements provide pure compound.

If you are interested in Dihydromyricetin or myricetin, please feel free to contact us at info@scigroundbio.com. We, at SciGround, are a professional product manufacturer and supplier specializing in these compounds, offering competitive prices and high-quality products.

References:

Liu AL, Wang HD, Lee SM, Wang YT, Du GH. Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities. Bioorg Med Chem. 2008;16(10):7141-7147.

Domitrović R, Jakovac H, Blagojević G. Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice. Toxicology. 2011;280(1-2):33-43.

Chen D, Cao G, Hastings T, et al. Molecular mechanism of dihydromyricetin-mediated alleviation of insulin resistance and hepatic lipid accumulation in vitro and in vivo. Biochem Pharmacol. 2013;86(4):519-531.

Thilakarathna SH, Vasantha Rupasinghe HP. Flavonoid bioavailability and attempts for bioavailability enhancement. Nutrients. 2013;5(9):3367-3387.

About Author

Celine Xu is a botanist with over 15 years of experience researching and developing plant extracts for nutritional and pharmaceutical applications. She leads an R&D team focused on identification, cultivation and extraction of medicinal plants. Celine Xu earned a Ph.D. in Plant Biology from UC Berkeley and has authored numerous articles in peer-reviewed journals about the health benefits of specific phytochemicals. She frequently speaks at industry conferences about new developments in plant extract research. Celine Xu is dedicated to advancing the scientific understanding of how targeted plant compounds can be used to improve human health.