Euphornin is a anticaner agent, that can be isolated from E. helioscopia. Euphornin induces apoptosis via caspase-mediated pathways. Euphornin induces cell cycle arrest by increasing the level of the phospho-CDK1 (Tyr15) protein.
Euphornin L is a jatrophane macrocyclic diterpenoid extracted from Euphorbia helioscopia. This compound is solid at room temperature. Has a potent anti-inflammatory property. It has a variety of important physiological activities, such as antibacterial, and antiviral, promoting angiogenesis and lipid-lowering effects.
In addition to its properties as a jatrophane macrocyclic diterpenoid, recent studies have shown that it increases LDLR protein levels in HepG2 cells through dual regulation of LDLR mRNA and PCSK9, making it an active compound for the development of lipid-lowering drugs.
The compound's unique properties make it a promising area of exploration for scientists and researchers in various fields. With continued research and exploration, we may see more and more applications and products harnessing the benefits of this fascinating natural compound.
Property Name | Property Value |
Molecular Weight | 626.7 g/mol |
XLogP3 -AA | 5.7 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 10 |
Rotatable Bond Count | 11 |
Exact Mass | 626.30909766 g/mol |
Monoisotopic Mass | 626.30909766 g/mol |
Topological Polar Surface Area | 132A2 |
Heavy Atom Count | 45 |
Formal Charge | 0 |
Complexity | 1180 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 8 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 2 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
1. Anti-inflammatory properties:
Euphornin L has been shown to inhibit inflammation in the body and reduce oxidative stress, which can lead to a wide range of chronic diseases.
2. Pain relief:
It has analgesic properties that can help to reduce pain, making it a promising natural remedy for conditions such as arthritis and other inflammatory conditions.
3. Antimicrobial activity:
It has been shown to have significant antimicrobial properties, meaning that it can help fight off infections caused by bacteria, viruses, and fungi.
4. Improved cognitive function:
Some research suggests that it may be beneficial for the brain, helping to improve cognitive function, memory, and attention.
5. Cardiovascular health:
It may help to improve cardiovascular health by reducing inflammation, promoting healthy blood flow, and supporting healthy cholesterol levels.
1. Pharmaceutical Industry:
It has gained attention in the pharmaceutical industry for its potential use in developing lipid-lowering drugs. Its ability to increase LDL receptor (LDLR) protein levels and reduce LDL cholesterol levels makes it a promising candidate for the treatment of hyperlipidemia and related cardiovascular conditions.
2. Nutraceuticals and Dietary Supplements:
It can be incorporated into nutraceuticals and dietary supplements aimed at promoting cardiovascular health. Its lipid-lowering properties make it a valuable addition to products designed to manage cholesterol levels naturally.
3. Biotechnology and Medical Research:
In biotechnology and medical research, it is studied for its mechanisms of action in regulating LDLR and PCSK9 proteins. Researchers explore its potential in understanding and developing therapies for lipid metabolism-related diseases.
4. Functional Foods and Beverages:
Euphornin L can be used in the formulation of functional foods and beverages. Its ability to lower LDL cholesterol levels may lead to the creation of health-conscious food and drink products, catering to consumers looking for heart-healthy options.
5. Cosmetic Industry:
Some cosmetic products may incorporate it due to their anti-inflammatory properties. It may be included in skincare formulations designed to soothe and reduce skin irritation.
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